Apply for a Computational Biologist / Bioinformatician job in Germany at TRON Mainz. Work on RNA-based precision therapies with AI and RNAseq.
Introduction
An exciting research opportunity is now open for an experienced Computational Biologist or Bioinformatician to contribute to the development of next-generation RNA-based precision therapies in Germany. This role is part of a core project within curATime (Cluster for Atherothrombosis and Individualized Medicine), a Clusters4Future initiative funded by the German Federal Ministry of Research, Technology and Space (BMFTR).
The position is based at TRON (Translational Oncology at the University Medical Center Mainz), within the Department for Cardiovascular Therapeutics, offering the chance to work at the cutting edge of translational science.
📌 Position Overview
- Position Title: Computational Biologist / Bioinformatician
- Research Area: RNA-based precision therapies
- Project: curATime (Clusters4Future)
- Host Institute: TRON
- Department: Cardiovascular Therapeutics
- Location: Mainz, Germany
- Job ID: 43601-01-26-WAPRO
- Work Mode: On-site / Hybrid
🔬 Key Responsibilities
In this role, you will focus on the design and optimization of programmable RNA switches (eToeholds) for cell type-specific translation in cardiovascular target cells.
Core Responsibilities Include:
- Analysis of trigger RNA expression using bulk and single-cell RNA-seq data
- In silico design of novel RNA architectures
- RNA structure modeling using tools such as ViennaRNA and NUPACK
- Molecular dynamics (MD) simulations (e.g., with GROMACS)
- AI- and data-driven optimization of RNA designs
- Building a systematic RNA design platform integrating reporter and preclinical data
- Close collaboration with experimental biologists for functional validation
🎓 Required Qualifications
Applicants should meet the following criteria:
- 🎓 PhD in Bioinformatics, Computational Biology, or a related field
- Strong experience with:
- Bulk and single-cell RNA-seq analysis
- RNA structure modeling
- MD simulations
- Proficiency in Python and R for statistical analysis and machine learning
- Experience working in Unix/Linux cluster environments
- Ability to develop reproducible computational workflows
- Solid background in molecular and cellular biology
- Excellent written and verbal communication skills
- Ability to work effectively in interdisciplinary research teams
💼 What TRON Offers
TRON provides a highly innovative and collaborative research environment with strong institutional support.
Benefits Include:
- 🌍 Diverse and international research team
- 💶 Performance-related remuneration
- 📚 Personalised training and career development
- 🚆 Subsidized Deutschlandticket (public transport)
- 🚲 Bike leasing program (BusinessBike)
- 🏡 Hybrid working options
- Access to state-of-the-art research infrastructure
- Strong collaborations with universities, hospitals, and industry partners
🏛️ About TRON
Founded in 2010 in Mainz, TRON is an internationally recognised institute for translational biomedical research. It bridges academic excellence and industrial-quality development, with a mission to develop innovative therapies for cancer, infectious diseases, and other serious conditions with high unmet medical need.
📝 How to Apply
Interested candidates should submit their application by email.
📄 Required Documents (Single PDF, max. 5 MB):
- Cover Letter
- Curriculum Vitae (CV)
- References
📧 Email: jobs(at)tron-mainz.de
📌 Subject / Reference: Job-ID 43601-01-26-WAPRO
🔗 More information: www.tron-mainz.de
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